2-Thiophenecarboxaldehyde, 5-chloro- → 4-Bromo-2-(5-chloro-2-thienylmethyl)-1-methoxynaphthalene

HRID 550034

Reaction equation

HRID 550034 reaction equation
Br[C:2]1[CH:11]=[C:10]([Br:12])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]=1[O:13][CH3:14].[Cl:15][C:16]1[S:20][C:19]([CH:21]=O)=[CH:18][CH:17]=1>>[Br:12][C:10]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([O:13][CH3:14])=[C:2]([CH2:21][C:19]2[S:20][C:16]([Cl:15])=[CH:17][CH:18]=2)[CH:11]=1

Participants

3

Reactant 2

HCID 817002-Thiophenecarboxaldehyde, 5-chloro-HCID 35720592,4-Dibromo-1-methoxynaphthalene

Product 1

HCID 666078244-Bromo-2-(5-chloro-2-thienylmethyl)-1-methoxynaphthalene

Procedure

2,4-Dibromo-1-methoxynaphthalene (see Org. Lett. (2003) 5, 831) and 5-chloro-2-thiophenecarboxaldehyde were treated in a manner similar to Reference Example 1 to give 4-Bromo-2-(5-chloro-2-thienylmethyl)-1-methoxynaphthalene.

Sources & evidence

ORD record
ord-2708f7893b0749749ce022132bec25b2
Source dataset
uspto-grants-2011_05
Patent number
US07943788B2

Linked notes

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