4-Chloro-7-methoxyquinazoline → HCID 22923408, compound

HRID 55037Notes

Reaction equation

HRID 55037 reaction equation
Br.[CH3:2][N:3]1[C:12]2[C:7](=[CH:8][C:9]([CH3:13])=[CH:10][CH:11]=2)[C:6](=[O:14])[N:5]([CH:15]2[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)[C:4]1=[O:21].Cl[C:23]1[C:32]2[C:27](=[CH:28][C:29]([O:33][CH3:34])=[CH:30][CH:31]=2)[N:26]=[CH:25][N:24]=1>>[CH3:34][O:33][C:29]1[CH:28]=[C:27]2[C:32]([C:23]([N:18]3[CH2:19][CH2:20][CH:15]([N:5]4[C:6](=[O:14])[C:7]5[C:12](=[CH:11][CH:10]=[C:9]([CH3:13])[CH:8]=5)[N:3]([CH3:2])[C:4]4=[O:21])[CH2:16][CH2:17]3)=[N:24][CH:25]=[N:26]2)=[CH:31][CH:30]=1

Participants

3

Reactant 2

HCID 189250784-Chloro-7-methoxyquinazolineHCID 218512221,2,3,4-Tetrahydro-1,6-dimethyl-2,4-dioxo-3-(4-piperidinyl)quinazoline hydrobromide2×

Product 1

HCID 22923408HCID 22923408, compoundYield 22%

Procedure

The procedure similar to that described in Example 57 was repeated, except that 354.0 g (1.0 mmol) of 1,2,3,4-tetrahydro-1,6-dimethyl-2,4-dioxo-3-(4-piperidinyl)-quinazoline hydrobromide (Compound v) obtained in Example 41 was used and 4-chloro-7-methoxyquinazoline was used in place of 4-chloro-6,7-dimethoxyquinazoline. As a result, 96.2 mg (yield: 22%) of Compound 85 was obtained as white crystals.

Workup

  1. customobtained in Example 41

Sources & evidence

ORD record
ord-dad194a54cf44a75b0356af89db6a78f
Source dataset
uspto-grants-1997_04
Patent number
US05624926

Reaction notes

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