2-Methylthiazole-5-carbohydrazide → 4-methyl-3-(2-methyl-1,3-thiazol-5-yl)-5-(4-penten-1-yl)-4H-1,2,4-triazole

Reaction equation

[CH3:1][C:2]1[S:3][C:4]([C:7]([NH:9][NH2:10])=O)=[CH:5][N:6]=1.Cl.[CH3:12][NH:13][C:14](=NC)[CH2:15][CH2:16][CH2:17][CH:18]=[CH2:19]>>[CH3:12][N:13]1[C:14]([CH2:15][CH2:16][CH2:17][CH:18]=[CH2:19])=[N:10][N:9]=[C:7]1[C:4]1[S:3][C:2]([CH3:1])=[N:6][CH:5]=1

Participants

Reactant 2

HCID 450844662-Methylthiazole-5-carbohydrazide

HCID 86630240N,N'-dimethyl-5-hexenimidamide hydrochloride

Product 1

HCID 576918664-methyl-3-(2-methyl-1,3-thiazol-5-yl)-5-(4-penten-1-yl)-4H-1,2,4-triazoleYield 43%

Procedure

The title compound was prepared in analogy to the method described in Preparation 11 starting from 2-methyl-1,3-thiazole-5-carbohydrazide and N,N′-dimethyl-5-hexenimidamide hydrochloride in 43% yield by column chromatography.

Sources & evidence

ORD record: ord-545a694e80cf4b75a277347d8f841aa2
Source dataset: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07947683B2

Reaction notes

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