3-Chloroaniline → 3-Phenylamino-pyrazine-2-carboxylic acid (3-chloro-phenyl)-amide

Reaction equation

CO[C:3]([C:5]1[C:10]([NH:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[N:9][CH:8]=[CH:7][N:6]=1)=[O:4].[Cl:18][C:19]1[CH:20]=[C:21]([CH:23]=[CH:24][CH:25]=1)[NH2:22]>>[Cl:18][C:19]1[CH:20]=[C:21]([NH:22][C:3]([C:5]2[C:10]([NH:11][C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[N:9][CH:8]=[CH:7][N:6]=2)=[O:4])[CH:23]=[CH:24][CH:25]=1

Participants

Reactant 2

HCID 79323-Chloroaniline

HCID 13370930Methyl 3-anilinopyrazine-2-carboxylate

Product 1

HCID 119966283-Phenylamino-pyrazine-2-carboxylic acid (3-chloro-phenyl)-amide

Procedure

The title compound, MS: m/e=325.1 (M+H+), was prepared in accordance with the general method of example 1, step 2 from 3-phenylamino-pyrazine-2-carboxylic acid methyl ester and 3-chloroaniline.

Sources & evidence

ORD record: ord-58949919edbd4867adea46e2125e7a12
Source dataset: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07947685B2

Reaction notes

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