Aluminium lithium hydride → 2-(4,5-Dimethyl-thiophen-2-yl)-ethylamine

Reaction equation

[CH3:1][C:2]1[S:3][C:4]([CH:8]=[CH:9][N+:10]([O-])=O)=[CH:5][C:6]=1[CH3:7].[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[CH3:7][C:6]1[CH:5]=[C:4]([CH2:8][CH2:9][NH2:10])[S:3][C:2]=1[CH3:1]

Participants

Reactant 2

HCID 21226445Aluminium lithium hydride

HCID 671948432,3-Dimethyl-5-(2-nitro-vinyl)-thiophene

Product 1

HCID 530135252-(4,5-Dimethyl-thiophen-2-yl)-ethylamineYield 55%

Procedure

In close analogy to the procedure described above, 2,3-Dimethyl-5-(2-nitro-vinyl)-thiophene is reacted with lithium aluminium hydride to provide the title compound.

Sources & evidence

ORD record: ord-0a32a97f96e04e41a68e80af72f7cb3b
Source dataset: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07947689B2

Reaction notes

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