Acetic Anhydride → N-[2-(4,5-Dimethyl-thiophen-2-yl)-ethyl]-acetamide

Reaction equation

[CH3:1][C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][NH2:10])[S:5][C:6]=1[CH3:7].[C:11](OC(=O)C)(=[O:13])[CH3:12]>>[CH3:1][C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][NH:10][C:11](=[O:13])[CH3:12])[S:5][C:6]=1[CH3:7]

Participants

Reactant 2

HCID 7918Acetic Anhydride

HCID 530135252-(4,5-Dimethyl-thiophen-2-yl)-ethylamine

Product 1

HCID 59663060N-[2-(4,5-Dimethyl-thiophen-2-yl)-ethyl]-acetamideYield 79%

Procedure

In close analogy to the procedure described above, 2-(4,5-Dimethyl-thiophen-2-yl)-ethylamine is reacted with acetic anhydride to provide the title compound.

Sources & evidence

ORD record: ord-9b73af21af4140ac8769ff493a85cb48
Source dataset: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07947689B2

Reaction notes

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