Phosphorus oxide (P4O10) → 4-Methyl-6,7-dihydro-furo[3,2-c]pyridine

Reaction equation

[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][CH2:7][NH:8][C:9](=O)[CH3:10].O=P12OP3(OP(OP(O3)(O1)=O)(=O)O2)=O>>[CH3:10][C:9]1[C:3]2[CH:4]=[CH:5][O:1][C:2]=2[CH2:6][CH2:7][N:8]=1

Participants

Reactant 2

HCID 14812Phosphorus oxide (P4O10)

HCID 40234725N-[2-(furan-2-yl)ethyl]acetamide

Product 1

HCID 596630784-Methyl-6,7-dihydro-furo[3,2-c]pyridineYield 94%

Procedure

In close analogy to the procedure described above, N-(2-Furan-2-yl-ethyl)-acetamide is reacted with phosphorus pentoxide to provide the title compound.

Sources & evidence

ORD record: ord-d4c60e4b5e28401f96eeacb1102d241a
Source dataset: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07947689B2

Reaction notes

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