Phosphorus oxide (P4O10) → 2,4-Dimethyl-6,7-dihydro-furo[3,2-c]pyridine

Reaction equation

[CH3:1][C:2]1[O:6][C:5]([CH2:7][CH2:8][NH:9][C:10](=O)[CH3:11])=[CH:4][CH:3]=1.O=P12OP3(OP(OP(O3)(O1)=O)(=O)O2)=O>>[CH3:1][C:2]1[O:6][C:5]2[CH2:7][CH2:8][N:9]=[C:10]([CH3:11])[C:4]=2[CH:3]=1

Participants

Reactant 2

HCID 14812Phosphorus oxide (P4O10)

HCID 59663075N-[2-(5-Methyl-furan-2-yl)-ethyl]-acetamide

Product 1

HCID 596630682,4-Dimethyl-6,7-dihydro-furo[3,2-c]pyridine

Procedure

In close analogy to the procedure described above, N-[2-(5-Methyl-furan-2-yl)-ethyl]-acetamide is reacted with phosphorus pentoxide to provide the title compound.

Sources & evidence

ORD record: ord-02736fdee46440d6bcf9703f59d3a79e
Source dataset: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07947689B2

Reaction notes

Loading…