4-Isocyanato-1,2-dimethoxybenzene → HCID 57445301, compound

HRID 550909

Reaction equation

HRID 550909 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:16]3[C:11](=[N:12][CH:13]=[CH:14][CH:15]=3)[NH:10][C:9]=2[C:17]([NH2:19])=[O:18])=[CH:4][CH:3]=1.[CH3:20][O:21][C:22]1[CH:23]=[C:24]([N:30]=[C:31]=[O:32])[CH:25]=[CH:26][C:27]=1[O:28][CH3:29]>>[CH3:20][O:21][C:22]1[CH:23]=[C:24]([NH:30][C:31](=[O:32])[NH:1][C:2]2[CH:3]=[CH:4][C:5]([C:8]3[C:16]4[C:11](=[N:12][CH:13]=[CH:14][CH:15]=4)[NH:10][C:9]=3[C:17]([NH2:19])=[O:18])=[CH:6][CH:7]=2)[CH:25]=[CH:26][C:27]=1[O:28][CH3:29]

Participants

3

Reactant 2

HCID 35178104-Isocyanato-1,2-dimethoxybenzeneHCID 574453543-(4-aminophenyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxamide

Product 1

HCID 57445301HCID 57445301, compound

Procedure

79 mg of solid beige-coloured 3-{4-[3-(3,4-dimethoxyphenyl)ureido]phenyl}-1H-pyrrolo[2,3-b]pyridine-2-carboxamide are prepared as described in Example 7 starting with 3-(4-aminophenyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxamide and 3,4-dimethoxyphenyl isocyanate.

Sources & evidence

ORD record
ord-46738f2b495d4015b941dbe8ceea411c
Source dataset
uspto-grants-2011_05
Patent number
US07947706B2

Linked notes

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