2,5-Dimethylphenyl isocyanate → 3-{4-[3-(2,5-dimethylphenyl)ureido]phenyl}-1H-pyrrolo-[2,3-c]pyridine-2-carboxamide

HRID 550937

Reaction equation

HRID 550937 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:16]3[C:11](=[CH:12][N:13]=[CH:14][CH:15]=3)[NH:10][C:9]=2[C:17]([NH2:19])=[O:18])=[CH:4][CH:3]=1.[CH3:20][C:21]1[CH:26]=[CH:25][C:24]([CH3:27])=[CH:23][C:22]=1[N:28]=[C:29]=[O:30]>>[CH3:20][C:21]1[CH:26]=[CH:25][C:24]([CH3:27])=[CH:23][C:22]=1[NH:28][C:29](=[O:30])[NH:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:16]3[C:11](=[CH:12][N:13]=[CH:14][CH:15]=3)[NH:10][C:9]=2[C:17]([NH2:19])=[O:18])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 986052,5-Dimethylphenyl isocyanateHCID 574453513-(4-aminophenyl)-1H-pyrrolo[2,3-c]pyridine-2-carboxamide

Product 1

HCID 574453363-{4-[3-(2,5-dimethylphenyl)ureido]phenyl}-1H-pyrrolo-[2,3-c]pyridine-2-carboxamide

Procedure

87 mg of solid yellow 3-{4-[3-(2,5-dimethylphenyl)ureido]phenyl}-1H-pyrrolo-[2,3-c]pyridine-2-carboxamide are prepared as described in Example 1 starting with 3-(4-aminophenyl)-1H-pyrrolo[2,3-c]pyridine-2-carboxamide and 2,5-dimethylphenyl isocyanate.

Sources & evidence

ORD record
ord-09e5e5508c494606ad46bdcd01134cc5
Source dataset
uspto-grants-2011_05
Patent number
US07947706B2

Linked notes

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