Ethyl 3-(2-benzyloxy-ethoxy)-propionate → Ethyl 3-(2-hydroxyethoxy)propanoate
Reaction equation
C([O:8][CH2:9][CH2:10][O:11][CH2:12][CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])C1C=CC=CC=1>C(O)C.[Pd]>[OH:8][CH2:9][CH2:10][O:11][CH2:12][CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
3.73 g (14.8 mmol) ethyl 3-(2-benzyloxy-ethoxy)-propionate are hydrogenated together with 665 mg 10% palladium charcoal in 70 ml of ethanol for 44 minutes at ambient temperature under a hydrogen atmosphere at 3 bar. Then the mixture is suction filtered and the filtrate is evaporated down i. vac.
Workup
- filtrationfiltered
- customthe filtrate is evaporated down i
Sources & evidence
- ORD record
- ord-3705c9c3a89048f8b0fcbda67a26d345
- Source dataset
- uspto-grants-2011_05
- Patent number
- US07947700B2
Reaction notes
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