3-Bromo-5-(trifluoromethyl)pyridine → HCID 24820877, compound

HRID 552498

Reaction equation

HRID 552498 reaction equation
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:4]=[N:5][CH:6]=[C:7](Br)[CH:8]=1.[CH3:12][C:13]1[N:14]=[C:15]([NH:18][C:19]([C:21]2[CH:26]=[C:25](B3OC(C)(C)C(C)(C)O3)[CH:24]=[C:23]([CH3:36])[N:22]=2)=[O:20])[S:16][CH:17]=1>>[CH3:12][C:13]1[N:14]=[C:15]([NH:18][C:19]([C:21]2[CH:26]=[C:25]([C:7]3[CH:6]=[N:5][CH:4]=[C:3]([C:2]([F:11])([F:10])[F:1])[CH:8]=3)[CH:24]=[C:23]([CH3:36])[N:22]=2)=[O:20])[S:16][CH:17]=1

Participants

3

Reactant 2

HCID 111279913-Bromo-5-(trifluoromethyl)pyridineHCID 497604122-Pyridinecarboxamide, 6-methyl-N-(4-methyl-2-thiazolyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)-

Product 1

HCID 24820877HCID 24820877, compound

Procedure

The title compound, was prepared from 3-Trifluoromethyl-5-bromopyridine and 6-Methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxa-borolan-2-yl)-pyridine-2-carboxylic acid (4-methyl-thiazol-2-yl)-amide in accordance with the general method of example 1, step 6 to yield the final compound as a white solid, MS (ISP): m/e=379.2 (M+H)+.

Sources & evidence

ORD record
ord-c8321f337ab9474b943419c693c60360
Source dataset
uspto-grants-2011_05
Patent number
US07951824B2

Linked notes

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