4-Bromo-2-fluoropyridine → HCID 24820878, compound

HRID 552499Notes

Reaction equation

HRID 552499 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]([NH:7][C:8]([C:10]2[CH:15]=[C:14](B3OC(C)(C)C(C)(C)O3)[CH:13]=[C:12]([CH3:25])[N:11]=2)=[O:9])[S:5][CH:6]=1.[F:26][C:27]1[CH:32]=[C:31](Br)[CH:30]=[CH:29][N:28]=1>>[CH3:1][C:2]1[N:3]=[C:4]([NH:7][C:8]([C:10]2[CH:15]=[C:14]([C:31]3[CH:30]=[CH:29][N:28]=[C:27]([F:26])[CH:32]=3)[CH:13]=[C:12]([CH3:25])[N:11]=2)=[O:9])[S:5][CH:6]=1

Participants

3

Reactant 2

HCID 27628514-Bromo-2-fluoropyridineHCID 497604122-Pyridinecarboxamide, 6-methyl-N-(4-methyl-2-thiazolyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)-

Product 1

HCID 24820878HCID 24820878, compound

Procedure

The title compound, was prepared from 6-Methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine-2-carboxylic acid (4-methyl-thiazol-2-yl)-amide in accordance with the general method of example 131, step 2 using 2-Fluoro-4-bromopyridine instead of 3-Trifluoromethyl-5-bromopyridine to yield the final compound as a white solid, MS (ISP): m/e=329.1 (M+H)+.

Sources & evidence

ORD record
ord-5b912757cd0840e8b6854a1fa7f44bc4
Source dataset
uspto-grants-2011_05
Patent number
US07951824B2

Reaction notes

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