4-Thiazoleacetonitrile, 2-amino- → HCID 24820901, compound
Reaction equation
C(O[C:4]([C:6]1[CH:11]=[C:10]([C:12]2[CH:17]=[C:16]([F:18])[CH:15]=[C:14]([F:19])[CH:13]=2)[CH:9]=[C:8]([CH3:20])[N:7]=1)=[O:5])C.[NH2:21][C:22]1[S:23][CH:24]=[C:25]([CH2:27][C:28]#[N:29])[N:26]=1>>[C:28]([CH2:27][C:25]1[N:26]=[C:22]([NH:21][C:4]([C:6]2[CH:11]=[C:10]([C:12]3[CH:13]=[C:14]([F:19])[CH:15]=[C:16]([F:18])[CH:17]=3)[CH:9]=[C:8]([CH3:20])[N:7]=2)=[O:5])[S:23][CH:24]=1)#[N:29]Participants
3
Procedure
The title compound, was prepared from 4-(3,5-Difluorophenyl)-6-methyl-pyridine-2-carboxylic acid ethyl ester in accordance with the general method of example 26, step 6 using (2-Amino-thiazol-4-yl)-acetonitrile instead of 3-chloroaniline to yield the final compound as a off-white solid, MS (ISP): m/e=371.2 (M+H)+.
Sources & evidence
- ORD record
- ord-5bcf35355aa043eca63467b12e7bec77
- Source dataset
- uspto-grants-2011_05