2-Amino-4-chloropyrimidine → 4-(3,5-Difluorophenyl)-6-methyl-pyridine-2-carboxylic acid (4-chloro-pyrimidin-2-yl)-amide

HRID 552528

Reaction equation

HRID 552528 reaction equation
C(O[C:4]([C:6]1[CH:11]=[C:10]([C:12]2[CH:17]=[C:16]([F:18])[CH:15]=[C:14]([F:19])[CH:13]=2)[CH:9]=[C:8]([CH3:20])[N:7]=1)=[O:5])C.[Cl:21][C:22]1[CH:27]=[CH:26][N:25]=[C:24]([NH2:28])[N:23]=1>>[Cl:21][C:22]1[CH:27]=[CH:26][N:25]=[C:24]([NH:28][C:4]([C:6]2[CH:11]=[C:10]([C:12]3[CH:13]=[C:14]([F:19])[CH:15]=[C:16]([F:18])[CH:17]=3)[CH:9]=[C:8]([CH3:20])[N:7]=2)=[O:5])[N:23]=1

Participants

3

Reactant 2

HCID 2233322-Amino-4-chloropyrimidineHCID 671639994-(3,5-Difluorophenyl)-6-methyl-pyridine-2-carboxylic acid ethyl ester

Product 1

HCID 866145894-(3,5-Difluorophenyl)-6-methyl-pyridine-2-carboxylic acid (4-chloro-pyrimidin-2-yl)-amide

Procedure

The title compound, was prepared from 4-(3,5-Difluorophenyl)-6-methyl-pyridine-2-carboxylic acid ethyl ester in accordance with the general method of example 26, step 6 using 4-Chloro-pyrimidin-2-ylamine instead of 3-chloroaniline to yield the final compound as a light brown solid, MS (ISP): m/e=361.1, 363.2 (M+H)+.

Sources & evidence

ORD record
ord-9a70d44ea71045e0b53d97fe731dc54b
Source dataset
uspto-grants-2011_05
Patent number
US07951824B2

Linked notes

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