1-Methyl-3-aminopyrazole → 6-Methyl-4-pyrimidin-5-yl-pyridine-2-carboxylic acid (1-methyl-1H-pyrazol-3-yl)-amide
Reaction equation
C(O[C:4]([C:6]1[CH:11]=[C:10]([C:12]2[CH:13]=[N:14][CH:15]=[N:16][CH:17]=2)[CH:9]=[C:8]([CH3:18])[N:7]=1)=[O:5])C.[NH2:19][C:20]1[CH:24]=[CH:23][N:22]([CH3:25])[N:21]=1>>[CH3:25][N:22]1[CH:23]=[CH:24][C:20]([NH:19][C:4]([C:6]2[CH:11]=[C:10]([C:12]3[CH:17]=[N:16][CH:15]=[N:14][CH:13]=3)[CH:9]=[C:8]([CH3:18])[N:7]=2)=[O:5])=[N:21]1Participants
3
Procedure
The title compound, was prepared from 6-Methyl-4-pyrimidin-5-yl-pyridine-2-carboxylic acid ethyl ester in accordance with the general method of example 26, step 6 using 3-Amino-1-methylpyrazole instead of 3-chloroaniline to yield the final compound as a gray crystalline, MS (ISP): m/e=295.2 (M+H)+.
Sources & evidence
- ORD record
- ord-87584020a02240ce95eb2ccf3c6fbb4e
- Source dataset
- uspto-grants-2011_05