5-Fluoro-4-methyl-1,3-thiazol-2-amine → HCID 86614594, compound
Reaction equation
C(O[C:4]([C:6]1[CH:11]=[C:10]([C:12]2[CH:17]=[C:16]([F:18])[CH:15]=[C:14]([F:19])[CH:13]=2)[CH:9]=[C:8]([CH3:20])[N:7]=1)=[O:5])C.[F:21][C:22]1[S:26][C:25]([NH2:27])=[N:24][C:23]=1[CH3:28]>>[F:21][C:22]1[S:26][C:25]([NH:27][C:4]([C:6]2[CH:11]=[C:10]([C:12]3[CH:13]=[C:14]([F:19])[CH:15]=[C:16]([F:18])[CH:17]=3)[CH:9]=[C:8]([CH3:20])[N:7]=2)=[O:5])=[N:24][C:23]=1[CH3:28]Participants
3
Procedure
The title compound, was prepared from 4-(3,5-Difluoro-phenyl)-6-methyl-pyridine-2-carboxylic acid ethyl ester in accordance with the general method of example 26, step 6 using 5-Fluoro-4-methyl-thiazol-2-ylamine instead of 3-Chloroaniline acid to yield the final compound as an orange solid, MS (ISP): m/e=364.2 (M+H)+.
Sources & evidence
- ORD record
- ord-4294dd1e6f9742c8bda68bf50f8c7bf6
- Source dataset
- uspto-grants-2011_05