Methyl iodide → 2-Iodo-3-methoxy-6-methylpyridine

HRID 55274

Reaction equation

[OH:1][C:2]1[C:3]([I:9])=[N:4][C:5]([CH3:8])=[CH:6][CH:7]=1.I[CH3:11]>>[I:9][C:3]1[C:2]([O:1][CH3:11])=[CH:7][CH:6]=[C:5]([CH3:8])[N:4]=1

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 899572-Iodo-6-methylpyridin-3-ol

Product 1

HCID 114820512-Iodo-3-methoxy-6-methylpyridine

Procedure

Under the conditions of example 1 D, 10 g of 3-hydroxy-2-iodo-6-methylpyridine is reacted with 2.7 ml of iodomethane and worked up. 10.5 g of 2-iodo-3-methoxy-6-methylpyridine of melting point 45°-50° C. is obtained.

Sources & evidence

ORD record: ord-f38c2634453445cb9ddfca9735a75e3d
Source dataset: uspto-grants-1997_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05624943

Linked notes

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