D-Thyroxine → Levothyroxine sodium monohydrate

HRID 553333

Reaction equation

C1C([O:7]C2C(I)=CC(C[C@H](N)C([O-])=O)=CC=2I)=CC(I)=C(O)C=1.[Na+:24].[CH:25]1[C:26]([CH2:43][C@@H:44]([NH2:48])[C:45]([OH:47])=[O:46])=[CH:27][C:28]([I:42])=[C:29]([O:32][C:33]2[CH:34]=[C:35]([I:41])[C:36]([OH:40])=[C:37]([I:39])[CH:38]=2)[C:30]=1[I:31]>>[CH:27]1[C:26]([CH2:43][C@H:44]([NH2:48])[C:45]([O-:47])=[O:46])=[CH:25][C:30]([I:31])=[C:29]([O:32][C:33]2[CH:38]=[C:37]([I:39])[C:36]([OH:40])=[C:35]([I:41])[CH:34]=2)[C:28]=1[I:42].[OH2:7].[Na+:24]

Participants

Reactant 2

HCID 8730D-Thyroxine

HCID 23666110Liothyronine Sodium

Product 1

HCID 23667619Levothyroxine sodium monohydrate

Procedure

liothyronine sodium; liotrix.

Sources & evidence

ORD record: ord-3f9283810a0642b095835da2808a05b0
Source dataset: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07951398B2

Linked notes

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