Methanol → 2-Hydroxybenzene-1-sulfonamide

HRID 553469

Reaction equation

HRID 553469 reaction equation
O(C[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[S:15](=[O:18])(=[O:17])[NH2:16])C1C=CC=CC=1.C[OH:20]>[Pd]>[OH:20][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[S:15](=[O:18])(=[O:17])[NH2:16]

Participants

4

Reactant 2

HCID 887MethanolHCID 669154671-(Phenoxymethyl)-2-sulfamoylbenzene

Product 1

HCID 6375462-Hydroxybenzene-1-sulfonamideYield 80%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

To a solution of crude 1-(phenoxymethyl)-2-sulfamoylbenzene (1.6 g, 6 mmol.) in 200 mL of methanol was added Pd/C (0.64 g). The reaction mixture was stirred at room temperature for 5 hours under H2 with a pressure of 30 psi. After the material was consumed, the reaction mixture was filtered. The solvent was evaporated to give crude 1-(hydroxy)-2-sulfamoylbenzene (800 mg, 80%) which was used directly without purification.

Workup

  1. customAfter the material was consumed
  2. filtrationthe reaction mixture was filtered
  3. customThe solvent was evaporated

Sources & evidence

ORD record
ord-be846d5394584773adf0d85bb04f447c
Source dataset
uspto-grants-2011_11
Patent number
US08048862B2

Linked notes

Loading…