Ethanol → HCID 58539475, compound

HRID 553667Notes

Reaction equation

HRID 553667 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=[O:11])[CH:5]=[CH:6][C:7]=1[F:8].S(=O)(=O)(O)O.[CH2:18](O)[CH3:19]>>[CH2:18]([O:11][C:10](=[O:12])[CH2:9][C:4]1[CH:5]=[CH:6][C:7]([F:8])=[C:2]([Br:1])[CH:3]=1)[CH3:19]

Participants

4

Reactant 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 34163393-Bromo-4-fluorophenylacetic Acid

Product 1

HCID 58539475HCID 58539475, compound

Procedure

3-Bromo-4-fluorophenylacetic acid (2.35 g, 9.0 mmol) was treated with concentrated sulfuric acid (2 mL) in ethanol (100 mL) at reflux for 2 hours. Purification by silica gel chromatography provided the title compound.

Workup

  1. temperatureat reflux for 2 hours
  2. customPurification by silica gel chromatography

Sources & evidence

ORD record
ord-32d87fdc44e04a67a8a5ea23d93adba3
Source dataset
uspto-grants-2011_11
Patent number
US08048902B2

Reaction notes

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