2,4-Dichlorobenzylamine → Gsk1370319A

HRID 554125

Reaction equation

HRID 554125 reaction equation
FC1C=CC(CN[C:10](=[O:18])[C@@H:11]2[CH2:15][CH2:14][C:13](=[O:16])[N:12]2[CH3:17])=C(C(F)(F)F)C=1.[Cl:23][C:24]1[CH:29]=[C:28]([Cl:30])[CH:27]=[CH:26][C:25]=1[CH2:31][NH2:32].FC1C=CC(CN)=C(C(F)(F)F)C=1>>[Cl:23][C:24]1[CH:29]=[C:28]([Cl:30])[CH:27]=[CH:26][C:25]=1[CH2:31][NH:32][C:10](=[O:18])[C@@H:11]1[CH2:15][CH2:14][C:13](=[O:16])[N:12]1[CH3:17]

Participants

4

Reactant 3

HCID 14852,4-DichlorobenzylamineHCID 2734878(4-Fluoro-2-(trifluoromethyl)phenyl)methanamineHCID 67458706N-{[4-fluoro-2-(trifluoromethyl)phenyl]methyl}-1-methyl-5-oxoprolinamide

Product 1

HCID 67461788Gsk1370319A

Procedure

N-[(2,4-dichlorophenyl)methyl]-1-methyl-5-oxoprolinamide was prepared in a manner analogous to that described above for the synthesis of N-{[4-fluoro-2-(trifluoromethyl)phenyl]methyl}-1-methyl-5-oxoprolinamide (Example 83) but [(2,4-dichlorophenyl)methyl]amine was substituted for {[4-fluoro-2-(trifluoromethyl)phenyl]methyl}amine.

Sources & evidence

ORD record
ord-dea8d8dbf8a446459a5e322827833688
Source dataset
uspto-grants-2011_11
Patent number
US08048907B2

Linked notes

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