HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tosylmethyl isocyanide → Ethyl 4-methyl-1h-pyrrole-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tosylmethyl isocyanide | HCID 161915 | — |
| Reactant | Ethyl trans-crotonate | HCID 429065 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Product | Ethyl 4-methyl-1h-pyrrole-3-carboxylate | HCID 235044 | 71.1% |
Reaction Steps
Using p-toluenesulfonylmethyl isocyanide (8.55 g), ethyl crotonate (5.0 g) and potassium tert-butoxide (5.90 g), a procedure as in Reference Example 39 was performed to give the title compound as a pale-yellow solid (yield 4.77 g, 71%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08048909B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-c31a5c841b6e47ee8805ad48720a6c35 |
| Source note | uspto-grants-2011_11 |