Tosylmethyl isocyanide → HCID 53632572, compound

HRID 554224

Reaction equation

C1(C)C=CC(S([CH2:10][N+:11]#[C-:12])(=O)=O)=CC=1.[C:14]([O:21][CH3:22])(=[O:20])/[CH:15]=[CH:16]/[CH2:17][CH2:18][CH3:19].CC(C)([O-])C.[K+]>>[CH2:17]([C:16]1[C:15]([C:14]([O:21][CH3:22])=[O:20])=[CH:10][NH:11][CH:12]=1)[CH2:18][CH3:19]

Participants

Reactant 3

HCID 161915Tosylmethyl isocyanide

HCID 5364409Methyl 2-hexenoate, (2E)-

HCID 23665647Potassium tert-butoxide

Product 1

HCID 53632572HCID 53632572, compoundYield 38%

Procedure

Using p-toluenesulfonylmethyl isocyanide (8.6 g), methyl (2E)-hex-2-enoate (5.67 g) and potassium tert-butoxide (5.9 g), a procedure as in Reference Example 39 was performed to give the title compound as colorless crystals (yield 2.8 g, 38%).

Sources & evidence

ORD record: ord-f80bb939a73a45eb906b7e3a74dd1bfb
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08048909B2

Linked notes

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