Phenol → 4-Acetoxy-2',5'-dichlorobenzophenone

Reaction equation

[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:17])[C:9]2[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=2[Cl:16])=[CH:4][CH:3]=1.[C:18]1([OH:24])C=CC=C[CH:19]=1.ClC1C=CC(Cl)=CC=1C(Cl)=O.C(Cl)(=O)C>>[C:18]([O:1][C:2]1[CH:3]=[CH:4][C:5]([C:8](=[O:17])[C:9]2[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=2[Cl:16])=[CH:6][CH:7]=1)(=[O:24])[CH3:19]

Participants

Reactant 4

HCID 996Phenol

HCID 6367Acetyl chloride

HCID 179452,5-Dichlorobenzoyl chloride

HCID 537038074'-Hydroxy-2,5-dichlorobenzophenone

Product 1

HCID 247230394-Acetoxy-2',5'-dichlorobenzophenone

Procedure

4'-Acetoxy-2,5-dichlorobenzophenone is prepared by treating 4'-Hydroxy-2,5-dichlorobenzophenone, which is prepared by the Friedel-Crafts acylation of phenol with 2,5-dichlorobenzoyl-chloride, with acetyl chloride.

Sources & evidence

ORD record: ord-dfbe1e82b8724e8cba9ff2d90af96eb8
Source dataset: uspto-grants-1997_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05625010

Reaction notes

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