methyl 2-chloro-5-{[(6E)-6-(5-chloro-2-methoxybenzylidene)-3,7-dioxo-1,4-diazepan-1-yl]sulfonyl}benzoate → Methyl 4-[(6-benzyl-3,7-dioxo-1,4-diazepan-1-yl)sulfonyl]benzoate

HRID 554784

Reaction equation

HRID 554784 reaction equation
[CH2:1]([CH:8]1[C:14](=[O:15])[N:13]([S:16]([C:19]2[CH:27]=[CH:26][C:22]([C:23]([OH:25])=[O:24])=[CH:21][CH:20]=2)(=[O:18])=[O:17])[CH2:12][C:11](=[O:28])[NH:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:29](OC(C1C=CC(S(N)(=O)=O)=CC=1)=O)(C)(C)C.C(C1C(=O)N(S(C2C=C(C=CC=2)C(O)=O)(=O)=O)CC(=O)NC1)C1C=CC=CC=1.C(OC(C1C=C(S(N)(=O)=O)C=CC=1)=O)(C)(C)C.ClC1C=CC(S(N2C(=O)/C(=C/C3C=C(Cl)C=CC=3OC)/CNC(=O)C2)(=O)=O)=CC=1C(OC)=O>>[CH2:1]([CH:8]1[C:14](=[O:15])[N:13]([S:16]([C:19]2[CH:27]=[CH:26][C:22]([C:23]([O:25][CH3:29])=[O:24])=[CH:21][CH:20]=2)(=[O:18])=[O:17])[CH2:12][C:11](=[O:28])[NH:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

6

Reactant 5

HCID 57670914methyl 2-chloro-5-{[(6E)-6-(5-chloro-2-methoxybenzylidene)-3,7-dioxo-1,4-diazepan-1-yl]sulfonyl}benzoateHCID 576710853-[(6-Benzyl-3,7-dioxo-1,4-diazepan-1-yl)sulfonyl]benzoic acidHCID 597336364-(Tert-butoxycarbonyl)benzenesulfonamideHCID 59733695Tert-butyl 3-sulfamoylbenzoateHCID 669347504-[(6-Benzyl-3,7-dioxo-1,4-diazepan-1-yl)sulfonyl]benzoic acid

Product 1

HCID 57670935Methyl 4-[(6-benzyl-3,7-dioxo-1,4-diazepan-1-yl)sulfonyl]benzoate

Procedure

4-[(6-benzyl-3,7-dioxo-1,4-diazepan-1-yl)sulfonyl]benzoic acid, synthesized by using 4-(tert-butoxycarbonyl)benzenesulfonamide instead of the starting material compound of Example 198, that is, 3-(tert-butoxycarbonyl)benzenesulfonamide for the similar procedure as in Example 198, was used instead of the starting material of Example 208, that is, the compound 196, for the similar procedure as with Example 208 to obtain the title compound.

Sources & evidence

ORD record
ord-c247d0df2ff7430a8a09e4602f7f8e44
Source dataset
uspto-grants-2011_11
Patent number
US08049006B2

Linked notes

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