HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Aminopyridine → 6-(5-Chloro-2-methoxybenzyl)-3,7-dioxo-n-{(1r)-1-[(3-pyridylamino)carbonyl]propyl}-1,4-diazepan-1-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Aminopyridine | HCID 10009 | — |
| Reactant | Glycine tert-butyl ester hydrochloride | HCID 2725036 | — |
| Reactant | Tert-butyl {[2-({[6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)butanoyl]amino}acetate | HCID 76588771 | — |
| Product | 6-(5-Chloro-2-methoxybenzyl)-3,7-dioxo-n-{(1r)-1-[(3-pyridylamino)carbonyl]propyl}-1,4-diazepan-1-carboxamide | HCID 57671034 | — |
Reaction Steps
Instead of the starting material compound of Example 220, that is, glycine tert-butyl ester hydrochloride, 3-aminopyridine was used for the similar procedure as in Example 220 to obtain the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08049006B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-de3a802e26084b81b40004ae7fe423db |
| Source note | uspto-grants-2011_11 |