3,5-Dihydroxybenzohydrazide → N'-[1-[1-(4-tert-butylphenyl)-3-methyl-5-oxopyrazol-4-ylidene]ethyl]-3,5-dihydroxybenzohydrazide
Reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([N:11]2[C:15]([OH:16])=[C:14]([C:17](=O)[CH3:18])[C:13]([CH3:20])=[N:12]2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[OH:21][C:22]1[CH:23]=[C:24]([CH:29]=[C:30]([OH:32])[CH:31]=1)[C:25]([NH:27][NH2:28])=[O:26]>>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([N:11]2[C:15](=[O:16])[C:14](=[C:17]([NH:28][NH:27][C:25](=[O:26])[C:24]3[CH:23]=[C:22]([OH:21])[CH:31]=[C:30]([OH:32])[CH:29]=3)[CH3:18])[C:13]([CH3:20])=[N:12]2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]Participants
3
Procedure
From 1-(1-(4-tert-butylphenyl)-5-hydroxy-3-methyl-1H-pyrazol-4-yl)-ethanone and 3,5-dihydroxybenzoic hydrazide, 40.1 mg of the desired product was obtained in the same manner as in Synthetic Example 1 as a yellow solid (yield 40%).
Sources & evidence
- ORD record
- ord-afbd5b4a80dc4875b1d30679572f3354
- Source dataset
- uspto-grants-2011_11