3,5-Dihydroxybenzohydrazide → N'-[1-[1-(3,4-dimethylphenyl)-3-methyl-5-oxopyrazol-4-ylidene]ethyl]-3,5-dihydroxybenzohydrazide
Reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([N:9]2[C:13]([OH:14])=[C:12]([C:15](=O)[CH3:16])[C:11]([CH3:18])=[N:10]2)[CH:5]=[CH:6][C:7]=1[CH3:8].[OH:19][C:20]1[CH:21]=[C:22]([CH:27]=[C:28]([OH:30])[CH:29]=1)[C:23]([NH:25][NH2:26])=[O:24]>>[CH3:1][C:2]1[CH:3]=[C:4]([N:9]2[C:13](=[O:14])[C:12](=[C:15]([NH:26][NH:25][C:23](=[O:24])[C:22]3[CH:21]=[C:20]([OH:19])[CH:29]=[C:28]([OH:30])[CH:27]=3)[CH3:16])[C:11]([CH3:18])=[N:10]2)[CH:5]=[CH:6][C:7]=1[CH3:8]Participants
3
Procedure
From 1-(1-(3,4-dimethylphenyl)-5-hydroxy-3-methyl-1H-pyrazol-4-yl)-ethanone and 3,5-dihydroxybenzoic hydrazide, 57.0 mg of the desired product was obtained in the same manner as in Synthetic Example 1 as a pale red solid (yield 73%).
Sources & evidence
- ORD record
- ord-03e42bb6f5af4064a24aac549bc75d53
- Source dataset
- uspto-grants-2011_11