Bromoacetonitrile → 2-(4-(Pyridin-3-yl)piperazin-1-yl)acetonitrile

HRID 555741

Reaction equation

[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([N:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH:2]=1.Br[CH2:14][C:15]#[N:16]>>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([N:7]2[CH2:8][CH2:9][N:10]([CH2:14][C:15]#[N:16])[CH2:11][CH2:12]2)[CH:2]=1

Participants

Reactant 2

HCID 11534Bromoacetonitrile

HCID 4372341-(Pyridin-3-yl)piperazine

Product 1

HCID 866417872-(4-(Pyridin-3-yl)piperazin-1-yl)acetonitrile

Procedure

The title compound is synthesized by coupling of 1-Pyridin-3-yl-piperazine and bromoacetonitrile analogously to the preparation of Intermediate 149.2 as a white solid; ES-MS: M+=203.2: AtRet=1.10.

Sources & evidence

ORD record: ord-9d8b3537edd34311b849611b4bcbbbc9
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08053457B2

Linked notes

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