Bromoacetonitrile → HCID 86641792, compound

Reaction equation

[NH:1]1[CH2:6][CH2:5][CH:4]([CH2:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=2)[CH2:3][CH2:2]1.Br[CH2:15][C:16]#[N:17]>>[N:9]1[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=1[CH2:7][CH:4]1[CH2:5][CH2:6][N:1]([CH2:15][C:16]#[N:17])[CH2:2][CH2:3]1

Participants

Reactant 2

HCID 11534Bromoacetonitrile

HCID 38006202-[(Piperidin-4-yl)methyl]pyridine

Product 1

HCID 86641792HCID 86641792, compound

Procedure

The title compound is synthesized by coupling of 2-Piperidin-4-ylmethyl-pyridine (commercially available from Array Biopharma) and bromoacetonitrile analogously to the preparation of Intermediate 149.2 as a colorless oil; ES-MS: M+=216.2.

Workup

customanalogously to the preparation of Intermediate 149.2 as a colorless oil

Sources & evidence

ORD record: ord-8c6225c6fee1424f8f8377ef533024da
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08053457B2

Reaction notes

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