Bromoacetonitrile → 2-[4-(2-Phenoxy-ethyl)-piperazin-1-yl]-acetonitrile

HRID 555771Notes

Reaction equation

HRID 555771 reaction equation
[O:1]([CH2:8][CH2:9][N:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[CH2:17][C:18]#[N:19]>>[O:1]([CH2:8][CH2:9][N:10]1[CH2:11][CH2:12][N:13]([CH2:17][C:18]#[N:19])[CH2:14][CH2:15]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 11534BromoacetonitrileHCID 2331871-(2-Phenoxyethyl)piperazine

Product 1

HCID 606988712-[4-(2-Phenoxy-ethyl)-piperazin-1-yl]-acetonitrile

Procedure

The title compound is synthesized by coupling of 1-(2-Phenoxy-ethyl)-piperazine (commercially available from CHESS GmbH) and bromoacetonitrile analogously to the preparation of Intermediate 149.2 as a colorless oil; ES-MS: M+H=246.2: CtRet=4.31.

Workup

  1. customanalogously to the preparation of Intermediate 149.2 as a colorless oil

Sources & evidence

ORD record
ord-62e3a69302d04d789bfe411f5188b9aa
Source dataset
uspto-grants-2011_11
Patent number
US08053457B2

Reaction notes

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