Bromoacetonitrile → HCID 63336725, compound

HRID 555773

Reaction equation

HRID 555773 reaction equation
[N:1]1([CH2:7][CH2:8][N:9]2[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.Br[CH2:16][C:17]#[N:18]>>[N:9]1([CH2:8][CH2:7][N:1]2[CH2:2][CH2:3][N:4]([CH2:16][C:17]#[N:18])[CH2:5][CH2:6]2)[CH2:10][CH2:11][O:12][CH2:13][CH2:14]1

Participants

3

Reactant 2

HCID 11534BromoacetonitrileHCID 27346404-(2-Piperazin-1-yl-ethyl)-morpholine

Product 1

HCID 63336725HCID 63336725, compound

Procedure

The title compound is synthesized by coupling of 4-(2-piperazin-1-yl-ethyl)-morpholine (commercially available from ABCR GmbH) and bromoacetonitrile analogously to the preparation of Intermediate 149.2 as a colorless oil; ES-MS: M+H=239.3; 1HNMR(DMSO-d6) 3.70 (s, 2H), 3.30 (bs, 4H), 2.60-2.30 (m, 16H).

Workup

  1. customanalogously to the preparation of Intermediate 149.2 as a colorless oil

Sources & evidence

ORD record
ord-33b1524a60bd41bea960f81682eb4fc5
Source dataset
uspto-grants-2011_11
Patent number
US08053457B2

Linked notes

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