Lawesson's reagent → 2-Ethyl-1-phenyl-1H-quinazolin-4-thione

HRID 557121

Reaction equation

HRID 557121 reaction equation
[CH2:1]([C:3]1[N:4]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:5]2[C:10]([C:11](=O)[N:12]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH3:2].COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:29])=CC=1>C1(C)C=CC=CC=1>[CH2:1]([C:3]1[N:4]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:5]2[C:10]([C:11](=[S:29])[N:12]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH3:2]

Participants

4

Reactant 2

HCID 87949Lawesson's reagentHCID 669910272-Ethyl-1-phenyl-1H-quinazolin-4-one

Product 1

HCID 866355292-Ethyl-1-phenyl-1H-quinazolin-4-thione

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

1.50 g (5.99 mmol) 2-ethyl-1-phenyl-1H-quinazolin-4-one and 2.42 g (5.99 mmol) Lawesson's reagent (C14H14O2P2S4, Fluka) were suspended in 40 ml toluene and boiled for 1 h. After evaporation the crude mixture was purified by column chromatography on silica gel, eluent dichloromethane/acetone 95/5.

Workup

  1. customAfter evaporation the crude mixture
  2. customwas purified by column chromatography on silica gel, eluent dichloromethane/acetone 95/5

Sources & evidence

ORD record
ord-551f6864684842a4b28a5737d7b2c144
Source dataset
uspto-grants-2011_11
Patent number
US08058431B2

Linked notes

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