Ethanol → Ethyl 1-(4-bromophenyl)cyclopropanecarboxylate
Reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([C:11]([OH:13])=[O:12])[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.S(=O)(=O)(O)O.[CH3:19][CH2:20]O>>[CH2:19]([O:12][C:11]([C:8]1([C:5]2[CH:4]=[CH:3][C:2]([Br:1])=[CH:7][CH:6]=2)[CH2:10][CH2:9]1)=[O:13])[CH3:20]Participants
4
Conditions
- Temperature
- 75 °C
Procedure
1-(4-Bromo-phenyl)-cyclopropanecarboxylic acid (5 g, 20.7 mmol) in EtOH (50 mL) was treated with sulfuric acid (2 mL), and the reaction was stirred at 75° C. for 1 hour. The mixture was worked up to give the title compound.
Sources & evidence
- ORD record
- ord-42645959858f4d19ae391684610069b7
- Source dataset
- uspto-grants-2011_11
- Patent number
- US08058300B2
Reaction notes
Loading…