4-Carboxyphenylboronic Acid → 4-(3-Chloro-6-methoxyquinolin-2-yl)benzoic acid

Reaction equation

Cl[C:2]1[C:11]([Cl:12])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([O:13][CH3:14])[CH:8]=2)[N:3]=1.B([C:18]1[CH:26]=[CH:25][C:21]([C:22]([OH:24])=[O:23])=[CH:20][CH:19]=1)(O)O>>[Cl:12][C:11]1[C:2]([C:18]2[CH:26]=[CH:25][C:21]([C:22]([OH:24])=[O:23])=[CH:20][CH:19]=2)=[N:3][C:4]2[C:9]([CH:10]=1)=[CH:8][C:7]([O:13][CH3:14])=[CH:6][CH:5]=2

Participants

Reactant 2

HCID 3121834-Carboxyphenylboronic Acid

HCID 397332932,3-Dichloro-6-methoxyquinoline2×

Product 1

HCID 669800214-(3-Chloro-6-methoxyquinolin-2-yl)benzoic acid

Procedure

Followed Scheme 3 where the starting materials were 2,3-dichloro-6-methoxyquinoline (Intermediate 4) and 4-boronobenzoic acid.

Sources & evidence

ORD record: ord-a385949fc06b408db7bfa60e8745d101
Source dataset: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09433618B2

Reaction notes

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