4-Amino-1,2,4-triazole → 4-methoxy-N-[1,2,4]triazol-4-yl-3-[(E)-2-(4-trifluoromethoxyphenyl)-vinyl]benzamide
Reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6]([C:7](O)=[O:8])=[CH:5][C:4]=1/[CH:12]=[CH:13]/[C:14]1[CH:19]=[CH:18][C:17]([O:20][C:21]([F:24])([F:23])[F:22])=[CH:16][CH:15]=1.[NH2:25][N:26]1[CH:30]=[N:29][N:28]=[CH:27]1>>[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([NH:25][N:26]2[CH:30]=[N:29][N:28]=[CH:27]2)=[O:8])=[CH:5][C:4]=1/[CH:12]=[CH:13]/[C:14]1[CH:19]=[CH:18][C:17]([O:20][C:21]([F:24])([F:23])[F:22])=[CH:16][CH:15]=1Participants
3
Procedure
The captioned compound was synthesized from 4-methoxy-3-[(E)-2-(4-trifluoromethoxyphenyl)vinyl]benzoic acid obtained in step B of Example 2-2-1 and 4-amino-1,2,4-triazole in accordance with the same procedure as in the methods described in step C of Example 1-2-3.
Sources & evidence
- ORD record
- ord-70cdbe7140a542b6933ddb97ab422bdf
- Source dataset
- uspto-grants-2011_11
- DOI