Morpholine → 4-((3-Bromophenyl)sulphonyl)morpholine

Reaction equation

[Br:1][C:2]1[CH:3]=[C:4]([S:8](Cl)(=[O:10])=[O:9])[CH:5]=[CH:6][CH:7]=1.[NH:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1>>[Br:1][C:2]1[CH:3]=[C:4]([S:8]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)(=[O:10])=[O:9])[CH:5]=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 8083Morpholine

HCID 17943m-Bromobenzenesulphonyl chloride

Product 1

HCID 36960024-((3-Bromophenyl)sulphonyl)morpholineYield 98%

Procedure

Prepared by general procedure III from 3-bromobenzenesulfonyl chloride (5.0 g, 20 mmol) and morpholine (1.89 g, 22 mmol) to give the title compound (5.9 g, 98%) as a white solid. MS (ISP) 306.1 [(M+H)+].

Sources & evidence

ORD record: ord-76574043b4e147229c1fbbe5f9eb76d4
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08063048B2

Reaction notes

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