ethyl 2-((tetrahydro-2H-pyran-2-yl)oxy)acetate → 1-[3-(2,4-Dichlorophenyl)-1,9-dimethyl-2-oxo-2,9-dihydro-1H-pyrido[2,3-b]indol-6-yl]-4-(tetrahydropyran-2-yloxy)butane-1,3-dione

HRID 559191

Reaction equation

HRID 559191 reaction equation
[C:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[N:9]([CH3:13])[C:8]1[N:14]([CH3:27])[C:15](=[O:26])[C:16]([C:18]3[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][C:19]=3[Cl:25])=[CH:17][C:7]2=1)(=[O:3])[CH3:2].C([O:30][C:31](=O)[CH2:32][O:33][CH:34]1[CH2:39][CH2:38][CH2:37][CH2:36][O:35]1)C>>[Cl:25][C:19]1[CH:20]=[C:21]([Cl:24])[CH:22]=[CH:23][C:18]=1[C:16]1[C:15](=[O:26])[N:14]([CH3:27])[C:8]2[N:9]([CH3:13])[C:10]3[C:6]([C:7]=2[CH:17]=1)=[CH:5][C:4]([C:1](=[O:3])[CH2:2][C:31](=[O:30])[CH2:32][O:33][CH:34]1[CH2:39][CH2:38][CH2:37][CH2:36][O:35]1)=[CH:12][CH:11]=3

Participants

3

Reactant 2

HCID 10899396ethyl 2-((tetrahydro-2H-pyran-2-yl)oxy)acetateHCID 669973096-acetyl-3-(2,4-dichlorophenyl)-1,9-dimethyl-1,9-dihydro-2H-pyrido[2,3-b]indol-2-one

Product 1

HCID 669974671-[3-(2,4-Dichlorophenyl)-1,9-dimethyl-2-oxo-2,9-dihydro-1H-pyrido[2,3-b]indol-6-yl]-4-(tetrahydropyran-2-yloxy)butane-1,3-dione

Procedure

The process is carried out as in Example 80 above, with the compound from preparation 1.10E, 6-acetyl-3-(2,4-dichlorophenyl)-1,9-dimethyl-1,9-dihydro-2H-pyrido[2,3-b]indol-2-one and (tetrahydropyran-2-yloxy)acetic acid ethyl ester.

Sources & evidence

ORD record
ord-4298017115e34b7d840cf9b7628d816f
Source dataset
uspto-grants-2011_11
Patent number
US08063061B2

Linked notes

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