2-(Trifluoromethyl)benzoic acid → 2-(Methylthio)-6-(trifluoromethyl)benzoic acid

Reaction equation

[F:1][C:2]([F:13])([F:12])[C:3]1[CH:11]=[CH:10][CH:9]=[CH:8][C:4]=1[C:5]([OH:7])=[O:6].[CH3:14][S:15]SC>>[CH3:14][S:15][C:8]1[CH:9]=[CH:10][CH:11]=[C:3]([C:2]([F:12])([F:13])[F:1])[C:4]=1[C:5]([OH:7])=[O:6]

Participants

Reactant 2

HCID 98992-(Trifluoromethyl)benzoic acid

HCID 12232Dimethyl Disulfide

Product 1

HCID 591979032-(Methylthio)-6-(trifluoromethyl)benzoic acid

Procedure

The title compound, white solid, MS: m/e=191.1 [(M−CO2H)−], was prepared in accordance with the general method of intermediate E from 2-(trifluoromethyl)benzoic acid and dimethyl disulfide.

Sources & evidence

ORD record: ord-4db86d3c0b4a41b598e867f8c7702f75
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08063098B2

Reaction notes

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