1-Piperidin-1-yl-cyclobutanecarbonitrile → C-Phenyl-C-(1-piperidin-1-yl-cyclobutyl)-methylamine

Reaction equation

[N:1]1([C:7]2([C:11]#[N:12])[CH2:10][CH2:9][CH2:8]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:13]1([Li])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[C:13]1([CH:11]([NH2:12])[C:7]2([N:1]3[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]3)[CH2:8][CH2:9][CH2:10]2)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

Reactant 2

HCID 438028681-Piperidin-1-yl-cyclobutanecarbonitrile2×

HCID 178506676HCID 178506676, compound

Product 1

HCID 59197915C-Phenyl-C-(1-piperidin-1-yl-cyclobutyl)-methylamine

Procedure

The title compound, light yellow liquid, MS: m/e=245.3 [(M+H)+], was prepared in accordance with the general method of intermediate B from 1-piperidin-1-yl-cyclobutanecarbonitrile (intermediate O) and phenyllithium.

Sources & evidence

ORD record: ord-8c6792bccb0943d0937757578ad56c3a
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08063098B2

Reaction notes

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