1-Morpholin-4-yl-cyclobutanecarbonitrile → C-(1-Morpholin-4-yl-cyclobutyl)-C-phenyl-methylamine

Reaction equation

[N:1]1([C:7]2([C:11]#[N:12])[CH2:10][CH2:9][CH2:8]2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[C:13]1([Li])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[N:1]1([C:7]2([CH:11]([NH2:12])[C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[CH2:10][CH2:9][CH2:8]2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Participants

Reactant 2

HCID 438029641-Morpholin-4-yl-cyclobutanecarbonitrile2×

HCID 178506676HCID 178506676, compound

Product 1

HCID 59197914C-(1-Morpholin-4-yl-cyclobutyl)-C-phenyl-methylamine

Procedure

The title compound, light yellow liquid, MS: m/e=247.3 [(M+H)+], was prepared in accordance with the general method of intermediate B from 1-morpholin-4-yl-cyclobutanecarbonitrile (intermediate T) and phenyllithium.

Sources & evidence

ORD record: ord-6636070661f246f0875247db5b5f3a70
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08063098B2

Reaction notes

Loading…