HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,3-Dihydro-1,4-benzodioxin-5-carboxylic acid → 2,3-Dihydro-benzo[1,4]dioxine-5-carboxylic acid[(1s,2s,5r)-3-(2-methyl-5-m-tolyl-thiazole-4-carbonyl)-3-aza-bicyclo[3.1.0]hex-2-ylmethyl]-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,3-Dihydro-1,4-benzodioxin-5-carboxylic acid | HCID 78184 | — |
| Reactant | ((1S,2S,5R)-2-Aminomethyl-3-aza-bicyclo[3.1.0]hex-3-yl)-(2-methyl-5-m-tolyl-thiazol-4-yl)-methanone | HCID 66998654 | — |
| Product | 2,3-Dihydro-benzo[1,4]dioxine-5-carboxylic acid[(1s,2s,5r)-3-(2-methyl-5-m-tolyl-thiazole-4-carbonyl)-3-aza-bicyclo[3.1.0]hex-2-ylmethyl]-amide | HCID 25182834 | — |
Reaction Steps
prepared by reaction of ((1S,2S,5R)-2-Aminomethyl-3-aza-bicyclo[3.1.0]hex-3-yl)-(2-methyl-5-m-tolyl-thiazol-4-yl)-methanone with 2,3-Dihydro-benzo[1,4]dioxine-5-carboxylic acid. LC-MS (basic): tR=0.88 min; [M+H]+=490.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063099B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-108f39736dd74053b1e4bbf458f160ce |
| Source note | uspto-grants-2011_11 |