HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Bromide → 2-(4-Ethoxyphenyl)thiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Bromide | HCID 6332 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-(1,3-Thiazol-2-yl)phenol | HCID 223840 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 2-(4-Ethoxyphenyl)thiazole | HCID 69160608 | 100% |
Reaction Steps
To a mixture of 2-(4-hydroxyphenyl)thiazole (21.27 g, 0.12 mol) and K2CO3 (82.93 g, 0.60 mol) in acetone (1000 mL) was added bromoethane (39.24 g, 0.36 mol) with stirring at rt. The reaction mixture was heated at 60° C. for 11 h, then cooled to rt, filtered and concentrated in vacuo to give the title compound as a white solid (24.54 g, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434695B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-1ffa6d2b914f46358351db5fa944536d |
| Source note | uspto-grants-2016_09 |