Ethyl 2-methyl-3-{7-[(methylsulfanyl)methyl]-1H-indol-3-yl}-3-[4-(trifluoromethyl)phenyl]propanoate → 2-Methyl-3-{7-[(methylsulfanyl)methyl]-1H-indol-3-yl}-3-[4-(trifluoromethyl)phenyl]propan-1-ol
Reaction equation
[CH3:1][CH:2]([CH:8]([C:19]1[C:27]2[C:22](=[C:23]([CH2:28][S:29][CH3:30])[CH:24]=[CH:25][CH:26]=2)[NH:21][CH:20]=1)[C:9]1[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=1)[C:3](OCC)=[O:4].BrC1SC(C(C2C3C(=C(CSC)C=CC=3)NC=2)CCO)=CN=1>>[CH3:1][CH:2]([CH:8]([C:19]1[C:27]2[C:22](=[C:23]([CH2:28][S:29][CH3:30])[CH:24]=[CH:25][CH:26]=2)[NH:21][CH:20]=1)[C:9]1[CH:10]=[CH:11][C:12]([C:15]([F:17])([F:18])[F:16])=[CH:13][CH:14]=1)[CH2:3][OH:4]Participants
3
Reactant 2
Product 1
Procedure
The title compound was prepared starting from 0.97 g (2.23 mmol) of the compound from Example 28A in analogy to the synthesis of the compound from Example 19. 0.66 g (75% of theory) of the title compound was obtained as mixture of diastereomers.