3-[(4-Fluoro-2-methylphenyl)(4-fluorophenyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indole → HCID 58392158, compound

HRID 561587

Reaction equation

HRID 561587 reaction equation
ClC1C=C(Cl)C=CC=1C([C:13]1[C:21]2[C:16](=[C:17]([CH2:23][S:24][CH3:25])[CH:18]=[C:19](F)[CH:20]=2)[NH:15][CH:14]=1)CCO.[Cl:26][C:27]1[CH:32]=[CH:31][C:30]([CH:33]([C:35]2[CH:40]=[CH:39][C:38]([F:41])=[CH:37][CH:36]=2)O)=[C:29]([F:42])[CH:28]=1.FC1C=CC(C(C2C=CC(F)=CC=2)C2C3C(=C(CSC)C=CC=3)NC=2)=C(C)C=1>>[Cl:26][C:27]1[CH:32]=[CH:31][C:30]([CH:33]([C:35]2[CH:40]=[CH:39][C:38]([F:41])=[CH:37][CH:36]=2)[C:13]2[C:21]3[C:16](=[C:17]([CH2:23][S:24][CH3:25])[CH:18]=[CH:19][CH:20]=3)[NH:15][CH:14]=2)=[C:29]([F:42])[CH:28]=1

Participants

4

Reactant 3

HCID 445952363-[(4-Fluoro-2-methylphenyl)(4-fluorophenyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indoleHCID 583923053-(2,4-Dichlorophenyl)-3-{5-fluoro-7-[(methylsulfanyl)methyl]-1H-indol-3-yl}propan-1-olHCID 58392437(4-Chloro-2-fluorophenyl)(4-fluorophenyl)methanol

Product 1

HCID 58392158HCID 58392158, compound

Procedure

The title compound was prepared starting from 1.50 g (8.46 mmol) of the compound from Example 8 and 2.15 g (8.46 mmol) of the compound from Example 85A in analogy to the synthesis of the compound from Example 101. A difference was, however, that stirring was at 80° C. for 3 h. 0.66 g (19% of theory) of the target compound was obtained.

Workup

  1. custom0.66 g (19% of theory) of the target compound was obtained

Sources & evidence

ORD record
ord-e0b04e2cda514190bccc23690854f4e1
Source dataset
uspto-grants-2011_11
Patent number
US08063234B2

Linked notes

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