Ammonia → (Z)-3-amino-N-(3-chloro-4-morpholinophenyl)but-2-enamide
Reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:14][C:15](=[O:20])[CH2:16][C:17](=O)[CH3:18])[CH:5]=[CH:6][C:7]=1[N:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1.[NH3:21]>CO>[NH2:21]/[C:17](/[CH3:18])=[CH:16]\[C:15]([NH:14][C:4]1[CH:5]=[CH:6][C:7]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)=[C:2]([Cl:1])[CH:3]=1)=[O:20]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of N-(3-chloro-4-morpholinophenyl)-3-oxobutanamide (2.0 g, 6.74 mmol), MeOH (15 mL) and ammonia (15 mL) was stirred at rt overnight. The mixture was then concentrated in vacuo to give the title compound, which was used for next step without further purification.
Workup
- concentrationThe mixture was then concentrated in vacuo
Sources & evidence
- ORD record
- ord-5acc8c99386740ccba8efb9ce2cdfd0a
- Source dataset
- uspto-grants-2016_09
- Patent number
- US09434695B2
Reaction notes
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