Sulfur dichloride → 3-(3-Fluorophenyl)propanoyl chloride
Reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][C:10]([OH:12])=O)[CH:5]=[CH:6][CH:7]=1.[Cl:13]SCl>>[F:1][C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][C:10]([Cl:13])=[O:12])[CH:5]=[CH:6][CH:7]=1Participants
3
Procedure
A mixture of 3-(3-fluorophenyl)propanoic acid (2.50 g, 14.9 mmol) and dichlorosulfane (10 mL) under N2 was refluxed for 3 h. The mixture was cooled to rt and concentrated in vacuo to give the title compound, which was used for next step without further purification.
Workup
- temperaturewas refluxed for 3 h
- concentrationconcentrated in vacuo
Sources & evidence
- ORD record
- ord-119617a6c7804e7aa0f70ecb08b9ebb9
- Source dataset
- uspto-grants-2016_09
- Patent number
- US09434695B2
Reaction notes
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