Sulfur dichloride → 3-(3-Fluorophenyl)propanoyl chloride

HRID 56247

Reaction equation

HRID 56247 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][C:10]([OH:12])=O)[CH:5]=[CH:6][CH:7]=1.[Cl:13]SCl>>[F:1][C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][C:10]([Cl:13])=[O:12])[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 25353Sulfur dichlorideHCID 27374893-(3-Fluorophenyl)propionic acid

Product 1

HCID 189935013-(3-Fluorophenyl)propanoyl chloride

Procedure

A mixture of 3-(3-fluorophenyl)propanoic acid (2.50 g, 14.9 mmol) and dichlorosulfane (10 mL) under N2 was refluxed for 3 h. The mixture was cooled to rt and concentrated in vacuo to give the title compound, which was used for next step without further purification.

Workup

  1. temperaturewas refluxed for 3 h
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-119617a6c7804e7aa0f70ecb08b9ebb9
Source dataset
uspto-grants-2016_09
Patent number
US09434695B2

Linked notes

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