Sulfur dichloride → 2-(Cyclohexyloxy)acetyl chloride

HRID 56266

Reaction equation

HRID 56266 reaction equation
[CH:1]1([O:7][CH2:8][C:9]([OH:11])=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:12]SCl>>[CH:1]1([O:7][CH2:8][C:9]([Cl:12])=[O:11])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 25353Sulfur dichlorideHCID 191994Cyclohexoxyacetic acid

Product 1

HCID 124841232-(Cyclohexyloxy)acetyl chloride

Procedure

A mixture of 2-(cyclohexyloxy)acetic acid (0.90 g, 5.69 mmol) and dichlorosulfane (10 mL) was refluxed for 2 h. The mixture was cooled to rt and concentrated in vacuo to give the title compound as yellow oil, which was used for next step without further purification.

Workup

  1. temperaturewas refluxed for 2 h
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-8af8cc706d3a457badbaab90d0f5f777
Source dataset
uspto-grants-2016_09
Patent number
US09434695B2

Linked notes

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