1-Bromo-5-chloropentane → 9-(5-Chloropentyl)-2-[(1-methylethyl)oxy]-8-(methyloxy)-9H-purin-6-amine
Reaction equation
Cl[CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[C:14]([O:15][CH3:16])=[N:13][C:12]2[C:7]1=[N:8][C:9]([O:18][C@@H:19]([CH3:22])[CH2:20]C)=[N:10][C:11]=2[NH2:17].FC(F)(F)C(O)=O.CC(OC1NC(N)=C2C(N=1)=NC(OC)=N2)C.BrCCCC[CH2:51][Cl:52]>>[Cl:52][CH2:51][CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[C:14]([O:15][CH3:16])=[N:13][C:12]2[C:7]1=[N:8][C:9]([O:18][CH:19]([CH3:20])[CH3:22])=[N:10][C:11]=2[NH2:17]Participants
4
Procedure
Prepared similarly to Intermediate 44 from 2-[(1-methylethyl)oxy]-8-(methyloxy)-1H-purin-6-amine trifluoroacetate and 1-bromo-5-chloropentane.